Pyridinium hydrochloride → HCID 69104888, compound

HRID 2224050Notes

Reaction equation

HRID 2224050 reaction equation
C[O:2][C:3]1[CH:20]=[CH:19][C:18]2[C@@H:17]3[C@:8]([CH:22]=[CH2:23])([C@H:9]4[C@@:13]([CH2:15][CH2:16]3)([CH3:14])[C:12](=[O:21])[CH2:11][CH2:10]4)[CH2:7][CH2:6][C:5]=2[CH:4]=1.Cl.[NH+]1C=CC=CC=1>>[OH:2][C:3]1[CH:20]=[CH:19][C:18]2[C@@H:17]3[C@:8]([CH:22]=[CH2:23])([C@H:9]4[C@@:13]([CH2:15][CH2:16]3)([CH3:14])[C:12](=[O:21])[CH2:11][CH2:10]4)[CH2:7][CH2:6][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 21584435Pyridinium hydrochlorideHCID 68657772HCID 68657772, compound

Product 1

HCID 69104888HCID 69104888, compound

Procedure

460 mg of 3-methoxy-8β-vinyl-estra-1,3,5(10)-trien-17-one was added to 9.2 g of pyridinium hydrochloride at 180° C. and stirred for 3 hours at the same temperature. Then, it was poured onto ice, the deposited precipitate was filtered off, washed with water and dried. The yield of 2-hydroxy-8β-vinyl-estra-1,3,5(10)-trien-17-one with a melting point of 239-242° C. amounted to 400 mg (90%).

Workup

  1. additionThen, it was poured onto ice
  2. filtrationthe deposited precipitate was filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-e2be8bd6d88b44a780c2284072e29eef
Source dataset
uspto-grants-2008_05
Patent number
US07378404B2

Reaction notes

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