反应详情

4-Benzenesulfonyl-2-nitro-phenol (6.37 g, 22.8 mmol), Pd/C (5%, 3 mg) and 1 mL of water were added to a flask, after which 45 mL of EtOH was added. The reaction mixture was stirred and purged with H2 (1 Atm). The reaction mixture was stirred under H2 for 4 hours, then filtered through celite. The filtrate was concentrated in vacuo to yield a crude oil, which was purified by flash chromatography (0-15% “magic base” (6:1:0.1 methylene chloride:methanol:ammonia) in dichloromethane) to afford 2-amino-4-benzenesulfonyl-phenol (2.695 g, 39%). MS: 250 (M+H)+.

1. custompurged with H2 (1 Atm)
2. stirringThe reaction mixture was stirred under H2 for 4 hours
3. filtrationfiltered through celite
4. concentrationThe filtrate was concentrated in vacuo
5. customto yield a crude oil, which
6. customwas purified by flash chromatography (0-15% “magic base” (6:1:0.1 methylene chloride:methanol:ammonia) in dichloromethane)