1-((1-Methyl-4-piperidinyl)methyl)piperazine → HCID 11502362, compound

HRID 2224107Notes

Reaction equation

HRID 2224107 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([CH2:8][N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH2:4][CH2:3]1.[C:15]1([CH:21]([N:28]=[C:29]=[O:30])[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(Cl)Cl>[CH:21]([NH:28][C:29]([N:12]1[CH2:13][CH2:14][N:9]([CH2:8][CH:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)[CH2:10][CH2:11]1)=[O:30])([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 27369421-((1-Methyl-4-piperidinyl)methyl)piperazineHCID 4250935(Isocyanatomethylene)dibenzene

Product 1

HCID 11502362HCID 11502362, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1-(1-methyl-piperidin-4ylmethyl)-piperazine (0.5 g, 2.7 mmol) in dry CH2Cl2 (12 ml) was added diphenylmethyl isocyanate (0.56 ml, 2.7 mmol) drop wise under nitrogen. The resulting mixture was stirred at room temperature over night. Removal of solvent under reduced pressure followed by column chromatography using CH2Cl2:CH3OH (10:1) gives the desired product in 82% yield.

Workup

  1. customRemoval of solvent under reduced pressure

Sources & evidence

ORD record
ord-c5a95079a6224491af444c26aa076df2
Source dataset
uspto-grants-2008_05
Patent number
US07378420B2

Reaction notes

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