Triphenylphosphine → HCID 69197382, compound

Participants

Reaction Steps

The title compound was prepared using 7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one, (50 mg, 0.14 mmol), prepared as described in Example 1, Ph3P (110 mg, 0.42 mmol) and (R)-5-(hydroxymethyl)pyrrolidin-2-one (17 mg, 0.14 mmol) in THF (1.0 mL) and by following the procedure described in Example 2. The title compound, (R)-7,8-bis(4-chlorophenyl)-2-((5-oxopyrrolidin-2-yl)methyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one, (38.5 mg, 85%) was obtained as yellow powder. MS M+H=454; 1H NMR (CDCl3) δ 8.15 (1H, s), 7.24-7.36 (6H, m), 7.09 (2H, d, J=10.0 Hz), 6.59 (1H, s), 4.17-4.20 (1H, m), 4.03-4.10 (2H, m), 2.25-2.35 (3H, m), 1.92-2.02 (1H, m).

Provenance & Evidence