Triphenylphosphine → HCID 59716728, compound

Participants

Reaction Steps

To a THF solution (2 ml) of 7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one, (40 mg, 0.11 mmol), prepared as described in Example 1, (1-benzyl-4-piperidyl)methanol (27 mg 0.13 mmol), and triphenylphospine (86 mg, 0.32 mmol) was added diethyl azodicarboxylate (0.15 ml, 0.38 mmol). After 1 hour, the reaction mixture was concentrated. The crude material was purified by preparative HPLC to give the title compound, 2-((1-benzylpiperidin-4-yl)methyl)-7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (6.1 mg, 10%) as a yellow solid. MS M+H=544; 1HNMR (CDCl3) δ 8.19 (1H), 7.42 (2H), 7.32-7.20 (9H), 7.11 (2H), 4.19 (1H), 4.02 (2H), 3.66 (2H), 2.63 (2H), 2.12 (2H), 1.91 (4H).

Provenance & Evidence