Triphenylphosphine → HCID 59716538, compound

Participants

Reaction Steps

To a THF solution (2 ml) of 7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one, (50 mg, 0.14 mmol), prepared as described in Example 1, 2-(phenylamino)ethanol (19 mg, 0.13 mmol), triphenylphosphine (55 mg, 0.21 mmol) was added diethyl azodicarboxylate (0.09 ml, 42% wt in toluene, 0.21 mmol). After 1 h, the reaction mixture was concentrated. The crude material was purified by preparative HPLC to give the title compound, 7,8-bis(4-chlorophenyl)-2-(2-(phenylamino)ethyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (14.4 mg, 23%) as a yellow solid. MS M+H=476; 1H NMR (CDCl3) δ 8.20 (1H), 7.41-7.20 (11H), 7.10 (2H), 4.51 (2H), 3.91 (2H).

Provenance & Evidence