Potassium Carbonate → HCID 69198236, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one, (20 mg, 0.056 mmol), prepared as described in Example 1, in 0.6 mL of DMF was added glycidyl isobutyl ether (7.3 mg, 0.056 mmol), followed by K2CO3 (15.5 mg, 0.112 mmol). The mixture was heated at 85° C. After stirring overnight, the reaction was allowed to cool to RT The reaction mixture was filtered to remove excess of K2CO3. The collected solution was concentrated under reduced pressure. The crude product was purified using reverse phase HPLC to give the title compound, 3,4-bis(4-chlorophenyl)-6-(2-hydroxy-3-isobutoxypropyl)imidazo[1,5-b]pyridazin-7(6H)-one (17.8 mg, 65% yield) as a yellow solid. in 65% yield. MS [M+H]+: found 487; 1H NMR (CDCl3, 400 MHz) δ 8.08 (s, 1H), 7.23-7.15 (m, 6H), 7.00-6.96 (m, 2H), 4.20-4.00 (m, 3H), 3.41 (d, 2H), 3.11 (d, 2H), 1.80-1.65 (m, 1H), 0.76 (d, 6H).

Provenance & Evidence