Water → HCID 59716568, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-benzyl-5-(4-fluorophenyl)-4-(pyridin-4-yl)pyridazin-3(2H)-one (1.04 g, 2.91 mmol) in toluene (15 mL) was added aluminum chloride (970 mg, 7.28 mmol). The reaction was stirred at 90° C. for 30 min. After cooling to RT, the reaction mixture was poured into water (50 mL). The resulting mixture was extracted with EtOAc (3×50 mL). The combined organic layers were washed with saturated aqueous NaHCO3, saturated aqueous NaCl. The organic layer was dried (Na2SO4), filtered and concentrated. The resulting residue was triturated with EtOAc-hexane to give the title compound, 5-(4-fluorophenyl)-4-(pyridin-4-yl)pyridazin-3(2H)-one as an off-white solid (560 mg, 70%). LC/MS (method A): RT=1.25 min, (M+H)+=268.

Provenance & Evidence