Methyl iodide → HCID 59716854, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the 7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (100 mg, 0.28 mmol), prepared as described in Example 1, in DMF (3 mL) at RT was added K2CO3 (116 mg, 0.84 mmol), followed by iodomethane (79 mg, 0.56 mmol). The reaction was heated at 60° C. for overnight. The reaction was diluted with EtOAc (20 mL), washed with saturated aqueous NaCl (20 mL×3). The organic layer was dried (MgSO4), filtered and concentrated under reduced pressure to give the title compound, 7,8-bis(4-chlorophenyl)-2-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one, (104 mg, 100%) as a yellow oil. HPLC retention time: 3.67 min; MS [M+H]+: found 371.

Provenance & Evidence