HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylboronic Acid → 6-Acetyl-3-fluoro-5,6-dihydro-2-phenylpyrido[3,2-c][1]benzazocine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | 6-Acetyl-3-fluoro-5,6-dihydro-2-(6-methoxy-3-pyridinyl)-pyrido[3,2-c][1]benzazocine | HCID 69291197 | — |
| Reactant | 6-Acetyl-2-chloro-3-fluoro-5,6-dihydro-pyrido[3,2-c][1]benzazocine | HCID 74393412 | — |
| Product | 6-Acetyl-3-fluoro-5,6-dihydro-2-phenylpyrido[3,2-c][1]benzazocine | HCID 69291524 | 88.5% |
Reaction Steps
The title compound (20.1 mg, 88.5%) was prepared from 1D (20.0 mg, 0.066 mmol) and phenylboronic acid (12.1 mg, 0.099 mmol) by a route analogous to that used for the preparation of 2B. HPLC Rt=3.326 min; LCMS Found: (M+H)+=345.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07378426B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-0514339962b84035bce4b9a411795892 |
| Source note | uspto-grants-2008_05 |