HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → 4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 5017741 | — |
| Reactant | 4-(5-bromopyridin-2-yl)morpholine | HCID 10966724 | — |
| Reactant | 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | HCID 16217714 | — |
| Product | 4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)morpholine | HCID 2795363 | 71% |
Reaction Steps
Compound 5A (616 mg, 71%) was prepared from 4-(5-bromo-pyridin-2-yl)-morpholine (727 mg, 2.99 mmol) and 2-isopropoxy-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (0.915 mL, 4.49 mmol) by a route analogous to that used for the preparation of 2A.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07378426B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-44a4e581a105453d9418872401eb80f9 |
| Source note | uspto-grants-2008_05 |