HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)morpholine → 6-Acetyl-8-chloro-3-fluoro-5,6-dihydro-2-[6-(4-morpholinyl)-3-pyridinyl]pyrido[3,2-c][1]benzazocine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)morpholine | HCID 2795363 | — |
| Reactant | 6-Acetyl-3-fluoro-5,6-dihydro-2-(6-methoxy-3-pyridinyl)-pyrido[3,2-c][1]benzazocine | HCID 69291197 | — |
| Reactant | 6-Acetyl-2,8-dichloro-3-fluoro-5,6-dihydropyrido[3,2-c][1]benzazocine | HCID 85424790 | — |
| Product | 6-Acetyl-8-chloro-3-fluoro-5,6-dihydro-2-[6-(4-morpholinyl)-3-pyridinyl]pyrido[3,2-c][1]benzazocine | HCID 69291055 | 52% |
Reaction Steps
The title compound (16.6 mg, 52%) was prepared from 6D (23.2 mg, 0.0688 mmol) and 5A (22 mg, 0.0722 mmol) by a route analogous to that used for the preparation of 2B. HPLC Rt=2.612 min; LCMS Found: (M+H)+=465.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07378426B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-a66dbf6a69fc4f70bac4889c53ac2c1d |
| Source note | uspto-grants-2008_05 |