2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → HCID 69289269, compound

HRID 2224321Notes

Reaction equation

HRID 2224321 reaction equation
COC1C=CC(B2OC(C)(C)C(C)(C)O2)=CN=1.[C:18]([N:21]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[CH:26]=[CH:25][C:24]2[N:33]=[C:34]([C:38]3[CH:39]=[N:40][C:41]([O:44][CH3:45])=[CH:42][CH:43]=3)[C:35](F)=[CH:36][C:23]=2[CH2:22]1)(=[O:20])[CH3:19]>>[C:18]([N:21]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[CH:26]=[CH:25][C:24]2[N:33]=[C:34]([C:38]3[CH:39]=[N:40][C:41]([O:44][CH3:45])=[CH:42][CH:43]=3)[CH:35]=[CH:36][C:23]=2[CH2:22]1)(=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 162177142-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridineHCID 692911976-Acetyl-3-fluoro-5,6-dihydro-2-(6-methoxy-3-pyridinyl)-pyrido[3,2-c][1]benzazocine

Product 1

HCID 69289269HCID 69289269, compoundYield 59%

Procedure

The title compound (14.8 mg, 59%) was prepared from 13C (20.0 mg, 0.07 mmol) and 2A (24.7 mg, 0.105 mmol) by a route analogous to that used for the preparation of 2B. HPLC Rt=2.612 min; LCMS Found: (M+H)+=358.

Sources & evidence

ORD record
ord-9fa86795173c4102b8e40c7eb52ed0ab
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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