4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)morpholine → HCID 69292412, compound

HRID 2224322Notes

Reaction equation

HRID 2224322 reaction equation
CC1(C)C(C)(C)OB([C:9]2[CH:10]=[CH:11][C:12]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[N:13][CH:14]=2)O1.[C:22]([N:25]1[C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=2[CH:30]=[CH:29][C:28]2[N:37]=[C:38](C3C=NC(OC)=CC=3)[C:39](F)=[CH:40][C:27]=2[CH2:26]1)(=[O:24])[CH3:23]>>[C:22]([N:25]1[C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=2[CH:30]=[CH:29][C:28]2[N:37]=[C:38]([C:9]3[CH:14]=[N:13][C:12]([N:15]4[CH2:16][CH2:17][O:18][CH2:19][CH2:20]4)=[CH:11][CH:10]=3)[CH:39]=[CH:40][C:27]=2[CH2:26]1)(=[O:24])[CH3:23]

Participants

3

Reactant 2

HCID 27953634-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)morpholineHCID 692911976-Acetyl-3-fluoro-5,6-dihydro-2-(6-methoxy-3-pyridinyl)-pyrido[3,2-c][1]benzazocine

Product 1

HCID 69292412HCID 69292412, compoundYield 91%

Procedure

The title compound (26.2 mg, 91%) was prepared from 13C (20.0 mg, 0.07 mmol) and 5A (30.5 mg, 0.105 mmol) by a route analogous to that used for the preparation of 2B. HPLC Rt=2.159 min; LCMS Found: (M+H)+=413.

Sources & evidence

ORD record
ord-06e9d39fe8dd494ba39a51d14ef9139b
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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