HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2224337Generated: October 30, 2026
Thionyl Chloride → 2,4-Dichloro-5-(chloromethyl)pyridine
https://huagongshe.com/reaction/2224337
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (4,6-Dichloropyridin-3-yl)methanol | HCID 2762727 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2,4-Dichloro-5-(chloromethyl)pyridine | HCID 2762728 | 47.3% |
Reaction Steps
To a stirred solution of 41A (2.5 g, 14 mmol) in CH2Cl2 (20 mL) was added slowly SOCl2 (1.2 mL, 14 mmol) at room temperature. The reaction was stirred for 15 minutes, cooled to 0° C. and washed with saturated aqueous NaHCO3. The CH2Cl2 layer was dried (MgSO4), concentrated in vacuo and purified by flash chromatography (SiO2, CH2Cl2) to give 41B (1.3 g, 47%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07378426B2 |
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| Source dataset | uspto-grants-2008_05 |
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| ORD ID | ord-bd18a2db729e4e7c8caf200efec7aa05 |
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| Source note | uspto-grants-2008_05 |
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