Acetic Acid → HCID 24738239, compound

Participants

Reaction Steps

Ethyl(4-{4-[(difluoromethyl)oxy]-9-[(1-methylethyl)oxy]-1,3-dioxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl}phenyl)acetate (0.14 g, 0.289 mmol) was heated to 100° C. in a 1:1 mixture of acetic acid:2N aqueous hydrochloric acid (8 ml) for 1 hour. The reaction was cooled to room temperature. On addition of water, the resulting white solid was collected by filtration and washed with water. This was dried in the vacuum oven to give the title compound (0.120 g, 0.026 mmol). LC/MS: Rt=3.36, [MH]+ 456.

Provenance & Evidence