HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)morpholine → 11-Acetyl-11,12-dihydro-3-[6-(4-morpholinyl)-3-pyridinyl]pyrido[3,4-c][1]benzazocine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)morpholine | HCID 2795363 | — |
| Reactant | 6-Acetyl-3-fluoro-5,6-dihydro-2-(6-methoxy-3-pyridinyl)-pyrido[3,2-c][1]benzazocine | HCID 69291197 | — |
| Reactant | 1-(3-chloro-12H-2,11-diaza-dibenzo[a,e]cycloocten-11-yl)-ethanone | HCID 72366777 | — |
| Product | 11-Acetyl-11,12-dihydro-3-[6-(4-morpholinyl)-3-pyridinyl]pyrido[3,4-c][1]benzazocine | HCID 69291008 | 12.1% |
Reaction Steps
The title compound (3.5 mg, 12%) was prepared from 41D (20 mg, 0.07 mmol) and 5A (30.5 mg, 0.105 mmol) by a route analogous to that used for the preparation of 2B. HPLC Rt=2.153 min; LCMS Found: (M+H)+=413.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07378426B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-43d19269df4d4496aa56e5f56c06b7c6 |
| Source note | uspto-grants-2008_05 |