HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichloro-5-(chloromethyl)pyridine → 11-Acetyl-3,8-dichloro-11,12-dihydropyrido[3,4-c][1]benzazocine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichloro-5-(chloromethyl)pyridine | HCID 2762728 | — |
| Reactant | N-(4-chloro-2-vinyl-phenyl)-acetamide | HCID 59717611 | — |
| Reactant | 6-Acetyl-2-chloro-3-fluoro-5,6-dihydro-pyrido[3,2-c][1]benzazocine | HCID 74393412 | — |
| Product | 11-Acetyl-3,8-dichloro-11,12-dihydropyrido[3,4-c][1]benzazocine | HCID 72366782 | 52% |
Reaction Steps
The title compound (67.6 mg, 52%) was prepared from 9B (80 mg, 0.41 mmol) and 41B (80 mg, 0.41 mmol) in two steps by a route analogous to that used for the preparation of 1D. HPLC Rt=2.886 min; LCMS Found: (M+H)+=319.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07378426B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-157fb17a9d5644609662bc3ac50e6347 |
| Source note | uspto-grants-2008_05 |