2-Bromomethyl-3-iodo-pyridine → N-(3-iodo-pyridin-2-ylmethyl)-N-(2-vinyl-phenyl)-acetamide

HRID 2224346Notes

Reaction equation

HRID 2224346 reaction equation
Br[CH2:2][C:3]1[C:8]([I:9])=[CH:7][CH:6]=[CH:5][N:4]=1.ClC1C(C[N:18]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[CH:28]=[CH2:29])[C:19](=[O:21])[CH3:20])=CC(F)=C(Cl)N=1>>[I:9][C:8]1[C:3]([CH2:2][N:18]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[CH:28]=[CH2:29])[C:19](=[O:21])[CH3:20])=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 571844822-Bromomethyl-3-iodo-pyridineHCID 59717570N-(2,6-dichloro-5-fluoro-pyridin-3-ylmethyl)-N-(2-vinyl-phenyl)-acetamide

Product 1

HCID 59717574N-(3-iodo-pyridin-2-ylmethyl)-N-(2-vinyl-phenyl)-acetamideYield 70%

Procedure

Compound 51C (8.5 mg, 70%) was prepared from bb (5.2 mg, 0.032 mmol) and 51B (9.7 mg, 0.33 mmol) by a route analogous to that used for the preparation of 1C. HPLC Rt=2.929 min.

Sources & evidence

ORD record
ord-955308d3ac7e499c886f64a99202ad61
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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