3,5-Dibromo-2-(bromomethyl)pyridine → HCID 69289275, compound

HRID 2224350Notes

Reaction equation

HRID 2224350 reaction equation
Br[C:2]1[C:3]([CH2:9]Br)=[N:4][CH:5]=[C:6]([Br:8])[CH:7]=1.[C:11]([N:14]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[CH:19]=[CH:18]C2N=C(Cl)C(F)=CC=2C1)(=[O:13])[CH3:12]>>[Br:8][C:6]1[CH:5]=[N:4][C:3]2[CH2:9][N:14]([C:11](=[O:13])[CH3:12])[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[CH:19]=[CH:18][C:2]=2[CH:7]=1

Participants

3

Reactant 2

HCID 534171773,5-Dibromo-2-(bromomethyl)pyridineHCID 743934126-Acetyl-2-chloro-3-fluoro-5,6-dihydro-pyrido[3,2-c][1]benzazocine

Product 1

HCID 69289275HCID 69289275, compoundYield 16%

Procedure

Compound 52C (46.6 mg, 16%) was prepared from bb (147 mg, 0.91 mmol) and 52B (300 mg, 0.91 mmol) in two steps by a route analogous to that used for the preparation of 1D.

Sources & evidence

ORD record
ord-3d5cd47010da4519b11aba15b72e33c1
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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