2-Amino-5-bromo-3-methylpyridine → 5-Bromo-2-chloro-3-methylpyridine

HRID 2224360Notes

Reaction equation

HRID 2224360 reaction equation
[Br:1][C:2]1[C:3](C)=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.Br[C:11]1C=C(C)C(N)=NC=1>>[Br:1][C:2]1[CH:7]=[C:6]([CH3:11])[C:5]([Cl:8])=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 1379342-Amino-5-bromo-3-methylpyridineHCID 148666743-Bromo-6-chloro-2-methylpyridine

Product 1

HCID 2854345-Bromo-2-chloro-3-methylpyridineYield 67%

Procedure

Compound 76A (1.8 g, 67%) was prepared using a procedure similar to the synthesis of 55A from 5-bromo-3-methyl-pyridin-2-ylamine.

Sources & evidence

ORD record
ord-1cd042a26ba043349d787ae43c964e81
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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