5-Bromo-2-chloro-3-methylpyridine → 5-Bromo-3-(bromomethyl)-2-chloropyridine

HRID 2224361Notes

Reaction equation

HRID 2224361 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH3:9])[C:5]([Cl:8])=[N:6][CH:7]=1.[Br:10]C1C(CBr)=NC(Cl)=CC=1>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][Br:10])[C:5]([Cl:8])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 2854345-Bromo-2-chloro-3-methylpyridineHCID 232499153-Bromo-2-(bromomethyl)-6-chloropyridine

Product 1

HCID 597175505-Bromo-3-(bromomethyl)-2-chloropyridineYield 33%

Procedure

Compound 76B (0.46 g, 33%) was prepared from 76A (1.0 g, 4.9 mmol) using a procedure similar to the synthesis of 55B.

Sources & evidence

ORD record
ord-41cec1ecd8004f7fbfe3e03c8b6726a1
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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