(2-Chloro-5-iodo-pyridin-4-yl)-methanol → 4-Bromomethyl-2-chloro-5-iodo-pyridine

HRID 2224363Notes

Reaction equation

HRID 2224363 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8]O)[C:5]([I:10])=[CH:4][N:3]=1.[Br:11]CC1C(Cl)=NC(Cl)=C(F)C=1>>[Br:11][CH2:8][C:6]1[C:5]([I:10])=[CH:4][N:3]=[C:2]([Cl:1])[CH:7]=1

Participants

3

Reactant 2

HCID 59717559(2-Chloro-5-iodo-pyridin-4-yl)-methanolHCID 597175733-(Bromomethyl)-2,6-dichloro-5-fluoropyridine

Product 1

HCID 597175634-Bromomethyl-2-chloro-5-iodo-pyridine

Procedure

Compound 77A was prepared from (2-Chloro-5-iodo-pyridin-4-yl)-methanol (0.2 g, 1.38 mmol) using a procedure similar to the synthesis of 1B.

Sources & evidence

ORD record
ord-64291521f11242a1ab78ec1c91710f34
Source dataset
uspto-grants-2008_05
Patent number
US07378426B2

Reaction notes

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