3-(Morpholine-4-sulfonyl)aniline → 7-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid[3-(morpholine-4-sulfonyl)-phenyl]-amide

HRID 2224409Notes

Reaction equation

HRID 2224409 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12](O)=[O:13])=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[N:27]1([S:33]([C:36]2[CH:37]=[C:38]([NH2:42])[CH:39]=[CH:40][CH:41]=2)(=[O:35])=[O:34])[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>>[N:27]1([S:33]([C:36]2[CH:37]=[C:38]([NH:42][C:12]([C:11]3[CH:10]=[N:9][N:8]4[C:3]([C:2]([F:1])([F:26])[F:25])=[CH:4][C:5]([C:15]5[CH:16]=[CH:17][C:18]([C:21]([F:23])([F:24])[F:22])=[CH:19][CH:20]=5)=[N:6][C:7]=34)=[O:13])[CH:39]=[CH:40][CH:41]=2)(=[O:35])=[O:34])[CH2:28][CH2:29][O:30][CH2:31][CH2:32]1

Participants

3

Reactant 2

HCID 5594103-(Morpholine-4-sulfonyl)anilineHCID 866071127-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 877697037-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid[3-(morpholine-4-sulfonyl)-phenyl]-amide

Procedure

The title compound was prepared from 7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.1) and 3-(morpholine-4-sulfonyl)-phenylamine [CAS 22184-97-0; commercially available] according to general procedure II. Yellow solid. MS (ISP) 600.3 [(M+H)+]; mp 233° C.

Sources & evidence

ORD record
ord-c540b4c98b6c4028bae7733f3b4b8dd9
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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