3-(Morpholine-4-sulfonyl)aniline → HCID 69293664, compound

HRID 2224418Notes

Reaction equation

HRID 2224418 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[C:13]([CH:15]([F:17])[F:16])[N:12]3[N:18]=[CH:19][C:20]([C:21]([OH:23])=O)=[C:11]3[N:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[N:24]1([S:30]([C:33]2[CH:34]=[C:35]([NH2:39])[CH:36]=[CH:37][CH:38]=2)(=[O:32])=[O:31])[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>>[N:24]1([S:30]([C:33]2[CH:34]=[C:35]([NH:39][C:21]([C:20]3[CH:19]=[N:18][N:12]4[C:13]([CH:15]([F:16])[F:17])=[CH:14][C:9]([C:4]5[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=5)=[N:10][C:11]=34)=[O:23])[CH:36]=[CH:37][CH:38]=2)(=[O:32])=[O:31])[CH2:25][CH2:26][O:27][CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 5594103-(Morpholine-4-sulfonyl)anilineHCID 4768478HCID 4768478, compound

Product 1

HCID 69293664HCID 69293664, compound

Procedure

The title compound was prepared from 5-(3,4-dichloro-phenyl)-7-difluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.7) and 3-(morpholine-4-sulfonyl)-phenylamine [CAS 22184-97-0; commercially available] according to general procedure II. Yellow solid. MS (ISP) 582.1 [(M+H)+]; mp 231° C.

Sources & evidence

ORD record
ord-f850c62d6dd2435fb5b6c3ed83b878e2
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

Loading…