3-(Morpholine-4-sulfonyl)aniline → HCID 87769170, compound

HRID 2224426Notes

Reaction equation

HRID 2224426 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:12]2[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[N:15]3[N:22]=[CH:23][C:24]([C:25]([OH:27])=O)=[C:14]3[N:13]=2)[CH:5]=[CH:6][C:7]=1[C:8]([F:11])([F:10])[F:9].[N:28]1([S:34]([C:37]2[CH:38]=[C:39]([NH2:43])[CH:40]=[CH:41][CH:42]=2)(=[O:36])=[O:35])[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>>[N:28]1([S:34]([C:37]2[CH:38]=[C:39]([NH:43][C:25]([C:24]3[CH:23]=[N:22][N:15]4[C:16]([C:18]([F:19])([F:21])[F:20])=[CH:17][C:12]([C:4]5[CH:5]=[CH:6][C:7]([C:8]([F:9])([F:11])[F:10])=[C:2]([CH3:1])[CH:3]=5)=[N:13][C:14]=34)=[O:27])[CH:40]=[CH:41][CH:42]=2)(=[O:36])=[O:35])[CH2:29][CH2:30][O:31][CH2:32][CH2:33]1

Participants

3

Reactant 2

HCID 5594103-(Morpholine-4-sulfonyl)anilineHCID 866071145-(3-Methyl-4-trifluoromethyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 87769170HCID 87769170, compound

Procedure

The title compound was prepared from 5-(3-methyl-4-trifluoromethyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.8) and 3-(morpholine-4-sulfonyl)-phenylamine [CAS 22184-97-0; commercially available] according to general procedure II. Yellow solid. MS (ISP) 614.4 [(M+H)+]; mp 272° C.

Sources & evidence

ORD record
ord-cad8071eed10442685cc245b06b36233
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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