3-(Morpholine-4-sulfonyl)aniline → HCID 87769448, compound

HRID 2224429Notes

Reaction equation

HRID 2224429 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:14]2[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[N:17]3[N:24]=[CH:25][C:26]([C:27]([OH:29])=O)=[C:16]3[N:15]=2)[CH:7]=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])[CH3:2].[N:30]1([S:36]([C:39]2[CH:40]=[C:41]([NH2:45])[CH:42]=[CH:43][CH:44]=2)(=[O:38])=[O:37])[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[N:30]1([S:36]([C:39]2[CH:40]=[C:41]([NH:45][C:27]([C:26]3[CH:25]=[N:24][N:17]4[C:18]([C:20]([F:23])([F:22])[F:21])=[CH:19][C:14]([C:6]5[CH:7]=[CH:8][C:9]([C:10]([F:11])([F:12])[F:13])=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=5)=[N:15][C:16]=34)=[O:29])[CH:42]=[CH:43][CH:44]=2)(=[O:38])=[O:37])[CH2:31][CH2:32][O:33][CH2:34][CH2:35]1

Participants

3

Reactant 2

HCID 5594103-(Morpholine-4-sulfonyl)anilineHCID 866071135-(3-Ethoxy-4-trifluoromethyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 87769448HCID 87769448, compound

Procedure

The title compound was prepared from 5-(3-ethoxy-4-trifluoromethyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.10) and 3-(morpholine-4-sulfonyl)-phenylamine [CAS 22184-97-0; commercially available] according to general procedure II. Yellow solid. MS (ISP) 642.2 [(M−H)−]; mp 235° C.

Sources & evidence

ORD record
ord-88b4da1c53584674af333b89a7c6c3d8
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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