3-(Morpholine-4-sulfonyl)aniline → HCID 69292791, compound

HRID 2224430Notes

Reaction equation

HRID 2224430 reaction equation
[F:1][CH:2]([F:28])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=O)=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[C:17]([O:25][CH2:26][CH3:27])[CH:16]=2)[CH:4]=1.[N:29]1([S:35]([C:38]2[CH:39]=[C:40]([NH2:44])[CH:41]=[CH:42][CH:43]=2)(=[O:37])=[O:36])[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>>[N:29]1([S:35]([C:38]2[CH:39]=[C:40]([NH:44][C:12]([C:11]3[CH:10]=[N:9][N:8]4[C:3]([CH:2]([F:28])[F:1])=[CH:4][C:5]([C:15]5[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:23])[F:24])=[C:17]([O:25][CH2:26][CH3:27])[CH:16]=5)=[N:6][C:7]=34)=[O:14])[CH:41]=[CH:42][CH:43]=2)(=[O:37])=[O:36])[CH2:30][CH2:31][O:32][CH2:33][CH2:34]1

Participants

3

Reactant 2

HCID 5594103-(Morpholine-4-sulfonyl)anilineHCID 66650197HCID 66650197, compound

Product 1

HCID 69292791HCID 69292791, compound

Procedure

The title compound was prepared from 7-difluoromethyl-5-(3-ethoxy-4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.12) and 3-(morpholine-4-sulfonyl)-phenylamine [CAS 22184-97-0; commercially available] according to general procedure II. Light yellow solid. MS (ISP) 624.3 [(M−H)−]; mp 231° C.

Sources & evidence

ORD record
ord-5c4d21468b7745ffbdfc4c727b3ffd63
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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