Benzenesulfonamide, 3-amino- → HCID 11635373, compound

HRID 2224432Notes

Reaction equation

[F:1][CH:2]([F:28])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12](O)=[O:13])=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[C:17]([O:25][CH2:26][CH3:27])[CH:16]=2)[CH:4]=1.[S:29]([C:33]1[CH:34]=[C:35]([NH2:39])[CH:36]=[CH:37][CH:38]=1)(=[O:32])(=[O:31])[NH2:30]>>[S:29]([C:33]1[CH:34]=[C:35]([NH:39][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([CH:2]([F:28])[F:1])=[CH:4][C:5]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:23])([F:24])[F:22])=[C:17]([O:25][CH2:26][CH3:27])[CH:16]=4)=[N:6][C:7]=23)=[O:13])[CH:36]=[CH:37][CH:38]=1)(=[O:31])(=[O:32])[NH2:30]

Participants

Reactant 2

HCID 7377Benzenesulfonamide, 3-amino-

HCID 66650197HCID 66650197, compound

Product 1

HCID 11635373HCID 11635373, compound

Procedure

The title compound was prepared from 7-difluoromethyl-5-(3-ethoxy-4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.12) and 3-sulfamoyl-phenylamine [commercially available] according to general procedure II. Light yellow solid. MS (ISP) 554.0 [(M−H)−]; mp 254° C.

Sources & evidence

ORD record: ord-01ab49ba387f4abeb5e1948de4e3fb25
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07378417B2

Reaction notes

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