3-amino-N-cyclopropylbenzenesulfonamide → HCID 11577941, compound

HRID 2224467Notes

Reaction equation

HRID 2224467 reaction equation
[F:1][CH:2]([F:28])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=O)=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[C:17]([O:25][CH2:26][CH3:27])[CH:16]=2)[CH:4]=1.[NH2:29][C:30]1[CH:31]=[C:32]([S:36]([NH:39][CH:40]2[CH2:42][CH2:41]2)(=[O:38])=[O:37])[CH:33]=[CH:34][CH:35]=1>>[CH:40]1([NH:39][S:36]([C:32]2[CH:31]=[C:30]([NH:29][C:12]([C:11]3[CH:10]=[N:9][N:8]4[C:3]([CH:2]([F:1])[F:28])=[CH:4][C:5]([C:15]5[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:22])[F:23])=[C:17]([O:25][CH2:26][CH3:27])[CH:16]=5)=[N:6][C:7]=34)=[O:14])[CH:35]=[CH:34][CH:33]=2)(=[O:38])=[O:37])[CH2:42][CH2:41]1

Participants

3

Reactant 2

HCID 53030613-amino-N-cyclopropylbenzenesulfonamideHCID 66650197HCID 66650197, compound

Product 1

HCID 11577941HCID 11577941, compound

Procedure

The title compound was prepared from 7-difluoromethyl-5-(3-ethoxy-4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.12) and 3-amino-N-cyclopropyl-benzenesulfonamide [CAS 459434-39-0] according to general procedure II. Yellow solid. MS (ISP) 594.1 [(M−H)−]; mp 213° C.

Sources & evidence

ORD record
ord-be26234063274637b096cb3c92563233
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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