Benzenesulfonamide, 3-amino- → HCID 11556368, compound

HRID 2224475Notes

Reaction equation

[F:1][C:2]([F:32])([F:31])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:15]2[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[N:18]3[N:25]=[CH:26][C:27]([C:28](O)=[O:29])=[C:17]3[N:16]=2)[CH:8]=[CH:9][C:10]=1[C:11]([F:14])([F:13])[F:12].[S:33]([C:37]1[CH:38]=[C:39]([NH2:43])[CH:40]=[CH:41][CH:42]=1)(=[O:36])(=[O:35])[NH2:34]>>[S:33]([C:37]1[CH:38]=[C:39]([NH:43][C:28]([C:27]2[CH:26]=[N:25][N:18]3[C:19]([C:21]([F:22])([F:24])[F:23])=[CH:20][C:15]([C:7]4[CH:8]=[CH:9][C:10]([C:11]([F:14])([F:13])[F:12])=[C:5]([O:4][CH2:3][C:2]([F:32])([F:31])[F:1])[CH:6]=4)=[N:16][C:17]=23)=[O:29])[CH:40]=[CH:41][CH:42]=1)(=[O:35])(=[O:36])[NH2:34]

Participants

Reactant 2

HCID 7377Benzenesulfonamide, 3-amino-

HCID 866071155-[3-(2,2,2-Trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 11556368HCID 11556368, compound

Procedure

The title compound was prepared from 5-[3-(2,2,2-trifluoroethoxy)-4-trifluoromethyl-phenyl]-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.10) and 3-sulfamoyl-phenylamine [commercially available] according to general procedure II. Yellow solid. MS (ISP) 626.1 [(M−H)−]; mp 233° C.

Sources & evidence

ORD record: ord-4cce2c14633d4660a1b6006348c81fd9
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07378417B2

Reaction notes

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