Benzenesulfonamide, 3-amino- → HCID 11527321, compound

HRID 2224476Notes

Reaction equation

[F:1][CH:2]([F:31])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=O)=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[C:17]([O:25][CH2:26][C:27]([F:30])([F:29])[F:28])[CH:16]=2)[CH:4]=1.[S:32]([C:36]1[CH:37]=[C:38]([NH2:42])[CH:39]=[CH:40][CH:41]=1)(=[O:35])(=[O:34])[NH2:33]>>[S:32]([C:36]1[CH:37]=[C:38]([NH:42][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([CH:2]([F:1])[F:31])=[CH:4][C:5]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:23])([F:24])[F:22])=[C:17]([O:25][CH2:26][C:27]([F:28])([F:30])[F:29])[CH:16]=4)=[N:6][C:7]=23)=[O:14])[CH:39]=[CH:40][CH:41]=1)(=[O:34])(=[O:35])[NH2:33]

Participants

Reactant 2

HCID 7377Benzenesulfonamide, 3-amino-

HCID 86611628HCID 86611628, compound

Product 1

HCID 11527321HCID 11527321, compound

Procedure

The title compound was prepared from 7-difluoromethyl-5-[3-(2,2,2-trifluoroethoxy)-4-trifluoromethyl-phenyl]-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.13) and 3-sulfamoyl-phenylamine [commercially available] according to general procedure II. Light yellow solid. MS (ISP) 607.9 [(M−H)−]; mp 241° C.

Sources & evidence

ORD record: ord-9e00d2fec7b340bd830a828719c0829e
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07378417B2

Reaction notes

Loading…