HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-amino-N-(2-hydroxyethyl)benzenesulfonamide → 7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [3-(2-hydroxy-ethylsulfamoyl)-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-amino-N-(2-hydroxyethyl)benzenesulfonamide | HCID 458782 | — |
| Reactant | 7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid | HCID 66650268 | — |
| Product | 7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [3-(2-hydroxy-ethylsulfamoyl)-phenyl]-amide | HCID 11519686 | — |
Reaction Steps
The title compound was prepared from 7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.1) and 3-amino-N-(2-hydroxy-ethyl)-benzenesulfonamide [CAS 436095-41-9] according to general procedure II. Light yellow solid. MS (ISP) 554.0 [(M−H)−]; mp 231° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07378417B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-c97b0d59f698443284c0fcebe5d93f9e |
| Source note | uspto-grants-2008_05 |