Benzenesulfonamide, 3-amino- → HCID 11554970, compound

HRID 2224481Notes

Reaction equation

HRID 2224481 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([CH:14]([F:16])[F:15])[N:11]3[N:17]=[CH:18][C:19]([C:20]([OH:22])=O)=[C:10]3[N:9]=2)=[CH:4][C:3]=1[CH3:23].[S:24]([C:28]1[CH:29]=[C:30]([NH2:34])[CH:31]=[CH:32][CH:33]=1)(=[O:27])(=[O:26])[NH2:25]>>[S:24]([C:28]1[CH:29]=[C:30]([NH:34][C:20]([C:19]2[CH:18]=[N:17][N:11]3[C:12]([CH:14]([F:16])[F:15])=[CH:13][C:8]([C:5]4[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([CH3:23])[CH:4]=4)=[N:9][C:10]=23)=[O:22])[CH:31]=[CH:32][CH:33]=1)(=[O:26])(=[O:27])[NH2:25]

Participants

3

Reactant 2

HCID 7377Benzenesulfonamide, 3-amino-HCID 66650512HCID 66650512, compound

Product 1

HCID 11554970HCID 11554970, compound

Procedure

The title compound was prepared from 5-(4-chloro-3-methyl-phenyl)-7-difluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.14) and 3-sulfamoyl-phenylamine [commercially available] according to general procedure II. Yellow solid. MS (EI) 491.1 [M]; mp 264° C.

Sources & evidence

ORD record
ord-19bd1a4e08c94ea2849187568bde5159
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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