3-Aminophenyl trifluoromethyl sulfone → HCID 11585073, compound

HRID 2224484Notes

Reaction equation

HRID 2224484 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12](O)=[O:13])=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[F:27][C:28]([F:40])([F:39])[S:29]([C:32]1[CH:33]=[C:34]([NH2:38])[CH:35]=[CH:36][CH:37]=1)(=[O:31])=[O:30]>>[F:40][C:28]([F:39])([F:27])[S:29]([C:32]1[CH:33]=[C:34]([NH:38][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([C:2]([F:26])([F:25])[F:1])=[CH:4][C:5]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:17][CH:16]=4)=[N:6][C:7]=23)=[O:13])[CH:35]=[CH:36][CH:37]=1)(=[O:30])=[O:31]

Participants

3

Reactant 2

HCID 27359433-Aminophenyl trifluoromethyl sulfoneHCID 866071127-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 11585073HCID 11585073, compound

Procedure

The title compound was prepared from 7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.2) and 3-trifluoromethanesulfonyl-phenylamine [commercially available] according to general procedure II. Yellow solid. MS (ISP) 583.3 [(M+H)+]; mp 207° C.

Sources & evidence

ORD record
ord-a3a59235241240f784d269baa2a499bd
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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