Ethanol, 2-[(3-aminophenyl)sulfonyl]- → 7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [3-(2-hydroxy-ethanesulfonyl)-phenyl]-amide

HRID 2224487Notes

Reaction equation

HRID 2224487 reaction equation
[F:1][CH:2]([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=O)=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[OH:26][CH2:27][CH2:28][S:29]([C:32]1[CH:33]=[C:34]([CH:36]=[CH:37][CH:38]=1)[NH2:35])(=[O:31])=[O:30]>>[OH:26][CH2:27][CH2:28][S:29]([C:32]1[CH:33]=[C:34]([NH:35][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([CH:2]([F:25])[F:1])=[CH:4][C:5]([C:15]4[CH:16]=[CH:17][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:19][CH:20]=4)=[N:6][C:7]=23)=[O:14])[CH:36]=[CH:37][CH:38]=1)(=[O:30])=[O:31]

Participants

3

Reactant 2

HCID 78905Ethanol, 2-[(3-aminophenyl)sulfonyl]-HCID 666502687-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 116638587-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [3-(2-hydroxy-ethanesulfonyl)-phenyl]-amide

Procedure

The title compound was prepared from 7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.1) and 3-(2-hydroxy-ethanesulfonyl)-aniline [commercially available] according to general procedure II. Yellow solid. MS (ISP) 541.4 [(M+H)+]; mp 205° C.

Sources & evidence

ORD record
ord-acbba0136b124c02af0980f92f6e38bf
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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