Benzenesulfonamide, 3-amino- → HCID 11613632, compound

HRID 2224495Notes

Reaction equation

HRID 2224495 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[CH:17]=[C:16]([CH:18]([F:20])[F:19])[N:15]3[N:21]=[CH:22][C:23]([C:24]([OH:26])=O)=[C:14]3[N:13]=2)[CH:5]=[CH:6][C:7]=1[C:8]([F:11])([F:10])[F:9].[S:27]([C:31]1[CH:32]=[C:33]([NH2:37])[CH:34]=[CH:35][CH:36]=1)(=[O:30])(=[O:29])[NH2:28]>>[S:27]([C:31]1[CH:32]=[C:33]([NH:37][C:24]([C:23]2[CH:22]=[N:21][N:15]3[C:16]([CH:18]([F:19])[F:20])=[CH:17][C:12]([C:4]4[CH:5]=[CH:6][C:7]([C:8]([F:11])([F:10])[F:9])=[C:2]([Cl:1])[CH:3]=4)=[N:13][C:14]=23)=[O:26])[CH:34]=[CH:35][CH:36]=1)(=[O:29])(=[O:30])[NH2:28]

Participants

3

Reactant 2

HCID 7377Benzenesulfonamide, 3-amino-HCID 86611629HCID 86611629, compound

Product 1

HCID 11613632HCID 11613632, compound

Procedure

The title compound was prepared from 5-(3-chloro-4-trifluoromethyl-phenyl)-7-difluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.15) and 3-sulfamoyl-phenylamine [commercially available] according to general procedure II. Brown solid. MS (ISP) 543.9 [(M−H)−]; mp 272° C.

Sources & evidence

ORD record
ord-517b6bc69a02413b964b6e2931b05d84
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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