Benzenesulfonamide, 3-amino- → HCID 11613622, compound

HRID 2224510Notes

Reaction equation

[F:1][C:2]([F:27])([F:26])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[N:13]3[N:20]=[CH:21][C:22]([C:23]([OH:25])=O)=[C:12]3[N:11]=2)=[CH:6][CH:5]=1.[S:28]([C:32]1[CH:33]=[C:34]([NH2:38])[CH:35]=[CH:36][CH:37]=1)(=[O:31])(=[O:30])[NH2:29]>>[S:28]([C:32]1[CH:33]=[C:34]([NH:38][C:23]([C:22]2[CH:21]=[N:20][N:13]3[C:14]([C:16]([F:17])([F:19])[F:18])=[CH:15][C:10]([C:7]4[CH:6]=[CH:5][C:4]([O:3][C:2]([F:26])([F:27])[F:1])=[CH:9][CH:8]=4)=[N:11][C:12]=23)=[O:25])[CH:35]=[CH:36][CH:37]=1)(=[O:30])(=[O:31])[NH2:29]

Participants

Reactant 2

HCID 7377Benzenesulfonamide, 3-amino-

HCID 87090280HCID 87090280, compound

Product 1

HCID 11613622HCID 11613622, compound

Procedure

The title compound was prepared from 5-(4-trifluoromethoxy-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.19) and 3-sulfamoyl-phenylamine [commercially available] according to general procedure II. Yellow solid. MS (ISP) 544.2 [(M−H)−]; mp 257° C.

Sources & evidence

ORD record: ord-324732b532e64971915cd7980667d7f2
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07378417B2

Reaction notes

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