Benzenesulfonamide, 3-amino- → HCID 11598484, compound

HRID 2224513Notes

Reaction equation

HRID 2224513 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[N:12]3[N:19]=[CH:20][C:21]([C:22](O)=[O:23])=[C:11]3[N:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].[S:25]([C:29]1[CH:30]=[C:31]([NH2:35])[CH:32]=[CH:33][CH:34]=1)(=[O:28])(=[O:27])[NH2:26]>>[S:25]([C:29]1[CH:30]=[C:31]([NH:35][C:22]([C:21]2[CH:20]=[N:19][N:12]3[C:13]([C:15]([F:17])([F:18])[F:16])=[CH:14][C:9]([C:4]4[CH:5]=[CH:6][C:7]([F:8])=[C:2]([F:1])[CH:3]=4)=[N:10][C:11]=23)=[O:23])[CH:32]=[CH:33][CH:34]=1)(=[O:27])(=[O:28])[NH2:26]

Participants

3

Reactant 2

HCID 7377Benzenesulfonamide, 3-amino-HCID 66650679HCID 66650679, compound

Product 1

HCID 11598484HCID 11598484, compound

Procedure

The title compound was prepared from 5-(3,4-difluoro-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.21) and 3-sulfamoyl-phenylamine [commercially available] according to general procedure II. Yellow solid. MS (ISP) 498.2 [(M+H)+]; mp 275° C.

Sources & evidence

ORD record
ord-86d822879bac41adb5133402e563dd7b
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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