HRID2224517

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID43498666

3-Amino-n-(2-hydroxy-1,1-dimethyl-ethyl)-benzenesulfonamide

C10H16N2O3S

结构：O=C(O)c1cnn2c(C(F)(F)F)cc(-c3ccc(C(F)(F)F)c(OCC(F)(F)F)c3)nc12

HCID86607115

未命名化合物

PRODUCTS

生成物

结构：CC(C)(CO)NS(=O)(=O)c1cccc(NC(=O)c2cnn3c(C(F)(F)F)cc(-c4ccc(C(F)(F)F)c(OCC(F)(F)F)c4)nc23)c1

HCID87769626

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 5-[3-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.10) and 3-amino-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzenesulfonamide (example B.8) according to general procedure II. Yellow solid. MS (ISP) 698.3 [(M−H−]; mp 251° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e123169607774463b3a6363f3a95059c
来源数据集: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07378417B2
来源说明: uspto-grants-2008_05

反应 SMILES

[F:1][C:2]([F:32])([F:31])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:15]2[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[N:18]3[N:25]=[CH:26][C:27]([C:28]([OH:30])=O)=[C:17]3[N:16]=2)[CH:8]=[CH:9][C:10]=1[C:11]([F:14])([F:13])[F:12].[NH2:33][C:34]1[CH:35]=[C:36]([S:40]([NH:43][C:44]([CH3:48])([CH3:47])[CH2:45][OH:46])(=[O:42])=[O:41])[CH:37]=[CH:38][CH:39]=1>>[OH:46][CH2:45][C:44]([NH:43][S:40]([C:36]1[CH:35]=[C:34]([NH:33][C:28]([C:27]2[CH:26]=[N:25][N:18]3[C:19]([C:21]([F:23])([F:24])[F:22])=[CH:20][C:15]([C:7]4[CH:8]=[CH:9][C:10]([C:11]([F:13])([F:14])[F:12])=[C:5]([O:4][CH2:3][C:2]([F:1])([F:31])[F:32])[CH:6]=4)=[N:16][C:17]=23)=[O:30])[CH:39]=[CH:38][CH:37]=1)(=[O:42])=[O:41])([CH3:48])[CH3:47]