3-Amino-n-(2-hydroxy-1,1-dimethyl-ethyl)-benzenesulfonamide → 5-[3-(2,2,2-Trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid[3-(2-hydroxy-1,1-dimethyl-ethylsulfamoyl)-phenyl]-amide
Reaction equation
[F:1][C:2]([F:32])([F:31])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:15]2[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[N:18]3[N:25]=[CH:26][C:27]([C:28]([OH:30])=O)=[C:17]3[N:16]=2)[CH:8]=[CH:9][C:10]=1[C:11]([F:14])([F:13])[F:12].[NH2:33][C:34]1[CH:35]=[C:36]([S:40]([NH:43][C:44]([CH3:48])([CH3:47])[CH2:45][OH:46])(=[O:42])=[O:41])[CH:37]=[CH:38][CH:39]=1>>[OH:46][CH2:45][C:44]([NH:43][S:40]([C:36]1[CH:35]=[C:34]([NH:33][C:28]([C:27]2[CH:26]=[N:25][N:18]3[C:19]([C:21]([F:23])([F:24])[F:22])=[CH:20][C:15]([C:7]4[CH:8]=[CH:9][C:10]([C:11]([F:13])([F:14])[F:12])=[C:5]([O:4][CH2:3][C:2]([F:1])([F:31])[F:32])[CH:6]=4)=[N:16][C:17]=23)=[O:30])[CH:39]=[CH:38][CH:37]=1)(=[O:42])=[O:41])([CH3:48])[CH3:47]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared from 5-[3-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.10) and 3-amino-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzenesulfonamide (example B.8) according to general procedure II. Yellow solid. MS (ISP) 698.3 [(M−H−]; mp 251° C.
Sources & evidence
- ORD record
- ord-e123169607774463b3a6363f3a95059c
- Source dataset
- uspto-grants-2008_05
- Patent number
- US07378417B2
Reaction notes
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