3-Amino-n-(2-hydroxy-1,1-dimethyl-ethyl)-benzenesulfonamide → HCID 87768440, compound

HRID 2224522Notes

Reaction equation

HRID 2224522 reaction equation
[F:1][C:2]([F:27])([F:26])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[N:13]3[N:20]=[CH:21][C:22]([C:23](O)=[O:24])=[C:12]3[N:11]=2)=[CH:6][CH:5]=1.[NH2:28][C:29]1[CH:30]=[C:31]([S:35]([NH:38][C:39]([CH3:43])([CH3:42])[CH2:40][OH:41])(=[O:37])=[O:36])[CH:32]=[CH:33][CH:34]=1>>[OH:41][CH2:40][C:39]([NH:38][S:35]([C:31]1[CH:30]=[C:29]([NH:28][C:23]([C:22]2[CH:21]=[N:20][N:13]3[C:14]([C:16]([F:17])([F:18])[F:19])=[CH:15][C:10]([C:7]4[CH:6]=[CH:5][C:4]([O:3][C:2]([F:27])([F:1])[F:26])=[CH:9][CH:8]=4)=[N:11][C:12]=23)=[O:24])[CH:34]=[CH:33][CH:32]=1)(=[O:37])=[O:36])([CH3:43])[CH3:42]

Participants

3

Reactant 2

HCID 434986663-Amino-n-(2-hydroxy-1,1-dimethyl-ethyl)-benzenesulfonamideHCID 87090280HCID 87090280, compound

Product 1

HCID 87768440HCID 87768440, compound

Procedure

The title compound was prepared from 5-(4-trifluoromethoxy-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.19) and 3-amino-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzenesulfonamide (example B.8) according to general procedure II. Yellow solid. MS (ISP) 618.3 [(M+H+]; mp 212° C.

Sources & evidence

ORD record
ord-3dd729bdcac34cbaa8e6f46ce3b180e7
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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