3-Amino-n-(2-hydroxy-1,1-dimethyl-ethyl)-benzenesulfonamide → HCID 69290140, compound

HRID 2224524Notes

Reaction equation

HRID 2224524 reaction equation
[F:1][CH:2]([F:28])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=O)=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[C:17]([O:25][CH2:26][CH3:27])[CH:16]=2)[CH:4]=1.[NH2:29][C:30]1[CH:31]=[C:32]([S:36]([NH:39][C:40]([CH3:44])([CH3:43])[CH2:41][OH:42])(=[O:38])=[O:37])[CH:33]=[CH:34][CH:35]=1>>[OH:42][CH2:41][C:40]([NH:39][S:36]([C:32]1[CH:31]=[C:30]([NH:29][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([CH:2]([F:28])[F:1])=[CH:4][C:5]([C:15]4[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:23])[F:24])=[C:17]([O:25][CH2:26][CH3:27])[CH:16]=4)=[N:6][C:7]=23)=[O:14])[CH:35]=[CH:34][CH:33]=1)(=[O:38])=[O:37])([CH3:44])[CH3:43]

Participants

3

Reactant 2

HCID 434986663-Amino-n-(2-hydroxy-1,1-dimethyl-ethyl)-benzenesulfonamideHCID 66650197HCID 66650197, compound

Product 1

HCID 69290140HCID 69290140, compound

Procedure

The title compound was prepared from 7-difluoromethyl-5-(3-ethoxy-4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.12) and 3-amino-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzenesulfonamide (example B.8) according to general procedure II. Light yellow solid. MS (ISP) 626.6 [(M−H−]; mp 250° C.

Sources & evidence

ORD record
ord-de4c50fa9cb6421f9954cc31e3634867
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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