3-amino-4-methylbenzenesulfonamide → HCID 87768348, compound

HRID 2224529Notes

Reaction equation

HRID 2224529 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12](O)=[O:13])=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[NH2:27][C:28]1[CH:29]=[C:30]([S:35]([NH2:38])(=[O:37])=[O:36])[CH:31]=[CH:32][C:33]=1[CH3:34]>>[CH3:34][C:33]1[CH:32]=[CH:31][C:30]([S:35](=[O:37])(=[O:36])[NH2:38])=[CH:29][C:28]=1[NH:27][C:12]([C:11]1[CH:10]=[N:9][N:8]2[C:3]([C:2]([F:1])([F:25])[F:26])=[CH:4][C:5]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:23])([F:22])[F:24])=[CH:17][CH:16]=3)=[N:6][C:7]=12)=[O:13]

Participants

3

Reactant 2

HCID 2355103-amino-4-methylbenzenesulfonamideHCID 866071127-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 87768348HCID 87768348, compound

Procedure

The title compound was prepared from 7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.2) and 3-amino-4-methyl-benzenesulfonamide [CAS-No. 6274-28-8; commercially available] according to general procedure II. Yellow solid. MS (ISP) 542.1 [(M−H−]; mp 310° C.

Sources & evidence

ORD record
ord-93adb60358b246f5bb986d4a56580f9a
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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