HCID 43498660, compound → HCID 87769093, compound

HRID 2224534Notes

Reaction equation

HRID 2224534 reaction equation
[F:1][CH:2]([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=O)=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[NH2:26][C:27]1[CH:28]=[C:29]([S:34]([NH:37][C:38]([CH3:42])([CH3:41])[CH2:39][OH:40])(=[O:36])=[O:35])[CH:30]=[CH:31][C:32]=1[Cl:33]>>[Cl:33][C:32]1[CH:31]=[CH:30][C:29]([S:34](=[O:36])(=[O:35])[NH:37][C:38]([CH3:41])([CH3:42])[CH2:39][OH:40])=[CH:28][C:27]=1[NH:26][C:12]([C:11]1[CH:10]=[N:9][N:8]2[C:3]([CH:2]([F:25])[F:1])=[CH:4][C:5]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:24])[F:23])=[CH:17][CH:16]=3)=[N:6][C:7]=12)=[O:14]

Participants

3

Reactant 2

HCID 43498660HCID 43498660, compoundHCID 666502687-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 87769093HCID 87769093, compound

Procedure

The title compound was prepared from 7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.1) and 3-amino-4-chloro-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzenesulfonamide (example B.10) according to general procedure II. Light yellow solid. MS (ISP) 616.2 [(M−H−]; mp 234° C.

Sources & evidence

ORD record
ord-277beab0c297459abd3690a1abcf2bdf
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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