HCID 43498657, compound → HCID 87769627, compound

HRID 2224535Notes

Reaction equation

HRID 2224535 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=O)=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.[NH2:27][C:28]1[CH:29]=[C:30]([S:35]([NH:38][C:39]([CH3:43])([CH3:42])[CH2:40][OH:41])(=[O:37])=[O:36])[CH:31]=[CH:32][C:33]=1[CH3:34]>>[OH:41][CH2:40][C:39]([NH:38][S:35]([C:30]1[CH:31]=[CH:32][C:33]([CH3:34])=[C:28]([NH:27][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([C:2]([F:26])([F:1])[F:25])=[CH:4][C:5]([C:15]4[CH:16]=[CH:17][C:18]([C:21]([F:22])([F:24])[F:23])=[CH:19][CH:20]=4)=[N:6][C:7]=23)=[O:14])[CH:29]=1)(=[O:37])=[O:36])([CH3:43])[CH3:42]

Participants

3

Reactant 2

HCID 43498657HCID 43498657, compoundHCID 866071127-Trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Product 1

HCID 87769627HCID 87769627, compound

Procedure

The title compound was prepared from 7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.2) and 3-amino-N-(2-hydroxy-1,1-dimethyl-ethyl)-4-methyl-benzenesulfonamide (example B. 11) according to general procedure II. Yellow solid. MS (ISP) 614.2 [(M−H−]; mp 240° C.

Sources & evidence

ORD record
ord-ffe379b2bef343d5a4cfb19247bc1a77
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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