7-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid → HCID 69290148, compound

HRID 2224536Notes

Reaction equation

HRID 2224536 reaction equation
[F:1][CH:2]([F:25])[C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12](O)=[O:13])=[C:7]2[N:6]=[C:5]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:4]=1.OCC([C:31]1[C:36]([N+:37]([O-])=O)=[C:35]([CH3:40])[CH:34]=[CH:33][C:32]=1[S:41]([NH2:44])(=[O:43])=[O:42])(C)C>>[OH:13][CH2:12][C:11]([NH:44][S:41]([C:32]1[CH:33]=[CH:34][C:35]([CH3:40])=[C:36]([NH:37][C:12]([C:11]2[CH:10]=[N:9][N:8]3[C:3]([CH:2]([F:25])[F:1])=[CH:4][C:5]([C:15]4[CH:16]=[CH:17][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:19][CH:20]=4)=[N:6][C:7]=23)=[O:13])[CH:31]=1)(=[O:42])=[O:43])([CH3:10])[CH3:7]

Participants

3

Reactant 2

HCID 666502687-Difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acidHCID 69288112HCID 69288112, compound

Product 1

HCID 69290148HCID 69290148, compound

Procedure

The title compound was prepared from 7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.1) and 3-amino-N-(2-hydroxy-1,1-dimethyl-ethyl)-4-methyl-benzenesulfonamide (example B.11) according to general procedure II. Light yellow solid. MS (ISP) 596.1 [(M−H−]; mp 214° C.

Sources & evidence

ORD record
ord-9f644b21425f4255b59ba893840cdbbf
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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