5-(4-Chloro-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid → HCID 69293567, compound

HRID 2224539Notes

Reaction equation

HRID 2224539 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:11]3[N:18]=[CH:19][C:20]([C:21]([OH:23])=O)=[C:10]3[N:9]=2)=[CH:4][CH:3]=1.[NH2:24][C:25]1[CH:26]=[C:27]([S:31]([NH:34][C:35]2([CH2:40][OH:41])[CH2:39][CH2:38][CH2:37][CH2:36]2)(=[O:33])=[O:32])[CH:28]=[CH:29][CH:30]=1>>[OH:41][CH2:40][C:35]1([NH:34][S:31]([C:27]2[CH:26]=[C:25]([NH:24][C:21]([C:20]3[CH:19]=[N:18][N:11]4[C:12]([C:14]([F:17])([F:15])[F:16])=[CH:13][C:8]([C:5]5[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=5)=[N:9][C:10]=34)=[O:23])[CH:30]=[CH:29][CH:28]=2)(=[O:33])=[O:32])[CH2:39][CH2:38][CH2:37][CH2:36]1

Participants

3

Reactant 2

HCID 532122235-(4-Chloro-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acidHCID 62522906HCID 62522906, compound

Product 1

HCID 69293567HCID 69293567, compound

Procedure

The title compound was prepared from 5-(4-chloro-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.4) and 3-amino-N-(1-hydroxymethyl-cyclopentyl)-benzenesulfonamide (example B.13) according to general procedure II. Yellow solid. MS (ISP) 594.0 [(M+H)+]; mp 253-255° C.

Sources & evidence

ORD record
ord-dc6c4edc6447486eb938e07dea1a26f0
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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