5-(4-Chloro-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid → HCID 69293023, compound

HRID 2224540Notes

Reaction equation

HRID 2224540 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:11]3[N:18]=[CH:19][C:20]([C:21](O)=[O:22])=[C:10]3[N:9]=2)=[CH:4][CH:3]=1.[NH2:24][C:25]1[CH:26]=[C:27]([S:31]([N:34]2[CH2:38][CH2:37][CH2:36][C@H:35]2[CH2:39][OH:40])(=[O:33])=[O:32])[CH:28]=[CH:29][CH:30]=1>>[OH:40][CH2:39][C@@H:35]1[CH2:36][CH2:37][CH2:38][N:34]1[S:31]([C:27]1[CH:26]=[C:25]([NH:24][C:21]([C:20]2[CH:19]=[N:18][N:11]3[C:12]([C:14]([F:15])([F:16])[F:17])=[CH:13][C:8]([C:5]4[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=4)=[N:9][C:10]=23)=[O:22])[CH:30]=[CH:29][CH:28]=1)(=[O:33])=[O:32]

Participants

3

Reactant 2

HCID 532122235-(4-Chloro-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acidHCID 69286981HCID 69286981, compound

Product 1

HCID 69293023HCID 69293023, compound

Procedure

The title compound was prepared from 5-(4-chloro-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.4) and (S)-[1-(3-amino-benzenesulfonyl)-pyrrolidin-2-yl]-methanol (example B.14) according to general procedure II. Pale-yellow solid. MS (ISP) 580.3 [(M+H)+]; mp 227-229° C.

Sources & evidence

ORD record
ord-777400a802ef4b9d8bfa326331bbdad2
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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