5-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid → HCID 69290624, compound

HRID 2224559Notes

Reaction equation

HRID 2224559 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([CH:14]3[CH2:16][CH2:15]3)[N:11]3[N:17]=[CH:18][C:19]([C:20]([OH:22])=O)=[C:10]3[N:9]=2)=[CH:4][CH:3]=1.[NH2:23][C:24]1[CH:25]=[C:26]([S:30]([N:33]2[CH2:37][CH2:36][CH2:35][C@H:34]2[CH2:38][OH:39])(=[O:32])=[O:31])[CH:27]=[CH:28][CH:29]=1>>[OH:39][CH2:38][C@@H:34]1[CH2:35][CH2:36][CH2:37][N:33]1[S:30]([C:26]1[CH:25]=[C:24]([NH:23][C:20]([C:19]2[CH:18]=[N:17][N:11]3[C:12]([CH:14]4[CH2:15][CH2:16]4)=[CH:13][C:8]([C:5]4[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=4)=[N:9][C:10]=23)=[O:22])[CH:29]=[CH:28][CH:27]=1)(=[O:32])=[O:31]

Participants

3

Reactant 2

HCID 666504695-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acidHCID 69286981HCID 69286981, compound

Product 1

HCID 69290624HCID 69290624, compound

Procedure

The title compound was prepared from 5-(4-chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.28) and (S)-[1-(3-amino-benzenesulfonyl)-pyrrolidin-2-yl]-methanol (example B.13) according to general procedure II. Pale-yellow solid. Mp 180-182° C.

Sources & evidence

ORD record
ord-ac86d3607b374fa582e94ea900db311e
Source dataset
uspto-grants-2008_05
Patent number
US07378417B2

Reaction notes

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