5-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid → HCID 69291857, compound

HRID 2224561Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([CH:14]3[CH2:16][CH2:15]3)[N:11]3[N:17]=[CH:18][C:19]([C:20]([OH:22])=O)=[C:10]3[N:9]=2)=[CH:4][CH:3]=1.OCC([C:28]1[C:33]([N+:34]([O-])=O)=[C:32]([CH3:37])[CH:31]=[CH:30][C:29]=1[S:38]([NH2:41])(=[O:40])=[O:39])(C)C>>[OH:22][CH2:20][C:19]([NH:41][S:38]([C:29]1[CH:30]=[CH:31][C:32]([CH3:37])=[C:33]([NH:34][C:20]([C:19]2[CH:18]=[N:17][N:11]3[C:12]([CH:14]4[CH2:15][CH2:16]4)=[CH:13][C:8]([C:5]4[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=4)=[N:9][C:10]=23)=[O:22])[CH:28]=1)(=[O:39])=[O:40])([CH3:18])[CH3:10]

Participants

Reactant 2

HCID 666504695-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

HCID 69288112HCID 69288112, compound

Product 1

HCID 69291857HCID 69291857, compound

Procedure

The title compound was prepared from 5-(4-chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (example C.28) and 3-amino-N-(2-hydroxy-1,1-dimethyl-ethyl)-4-methyl-benzenesulfonamide (example B.11) according to general procedure II. Pale-yellow solid. MS (ISP) 554.3 [(M+H)+].

Sources & evidence

ORD record: ord-61c0a229187b4505b01841a2ee152d5c
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07378417B2

Reaction notes

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